Modulation of Autophagy and Mitochondrial Dynamics Gene Expression by Turmeric and Mangosteen Peel Extract

High fat diet (HFD) induces oxidative stress and mitochondrial dysfunction which culminates in fatty liver disease. Autophagy dynamics are affected by HFD. Turmeric mangosteen have potential roles as antioxidants regulators of function the liver. The study aims to examine effect turmeric peel extract on autophagy after HFD induction. Five groups animals (n=5) used: negative control, positive control (HFD), (HFD + 270 mg/kg BW extract), fenofibrate 15 fenofibrate). was given for 7 weeks, continued another weeks plus treatment. Liver sections were extracted conduct semi-quantitative PCR. (LC3, p62), mitophagy (Pink1, Parkin, Bnip3), fission (Drp1, Fis1), fusion (Opa1, Mfn1, Mfn2) gene expression measured. LC3 (p=0.048), p62 (p=0.043), Pink1 (p=0.012), Bnip3 (p=0.010), Mfn1 (p=0.015), Mfn2 (p=0.035) expressions differed significantly, while Parkin (p=0.098) Drp1 (p=0.962), Fis1 (p=0.570), Opa1 (p=0.055) did not differ between groups. Both effects activating autophagy, mitophagy, rat induced